LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012730

UniProt Annotations

Entry Information
Gene NameUDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6
Protein EntryB4GT6_RAT
UniProt IDO88419
SpeciesRat
Comments
Comment typeDescription
Biophysicochemical PropertiespH dependence: Optimum pH is 7.2.;
Catalytic ActivityUDP-alpha-D-galactose + beta-D-glucosyl- (1<->1)-ceramide = UDP + beta-D-galactosyl-(1->4)-beta-D-glucosyl- (1<->1)-ceramide
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= ;
Enzyme RegulationInhibited by EDTA.
FunctionRequired for the biosynthesis of glycosphingolipids
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the glycosyltransferase 7 family
Subcellular LocationGolgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein . Note=Trans cisternae of Golgi stack
Tissue SpecificityHighest expression in brain with lower levels found in lungs, heart, skeletal muscle and kidney. Lowest expression in testis, liver and spleen