LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012734

UniProt Annotations

Entry Information
Gene Nameacetoacetyl-CoA synthetase
Protein EntryAACS_RAT
UniProt IDQ9JMI1
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA
FunctionActivates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development.
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family
Subcellular LocationCytoplasm, cytosol .
Tissue SpecificityAbundant in male subcutaneous white adipose tissue after weaning. In white adipose tissue, it is preferentially detected in mature adipocytes but not in preadipocytes. The expression in primary preadipocytes increases during the adipocyte differentiation. In brain, it is expressed in the midbrain, pons/medulla, cerebral cortex, hippocampus and cerebellum. The expression in the cerebellum is restricted primarily to glial cells, while in the cerebral cortex, it is restricted to neuronal cells. {ECO:0000269|PubMed:15992942, ECO:0000269|PubMed:16055091}.