LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012746

UniProt Annotations

Entry Information
Gene Namenuclear receptor subfamily 4, group A, member 1
Protein EntryNR4A1_RAT
UniProt IDP22829
SpeciesRat
Comments
Comment typeDescription
FunctionOrphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'- AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity)
InductionBy nerve growth factor and during liver regeneration.
PtmAcetylated by p300/CBP, acetylation increases stability. Deacetylated by HDAC1 (By similarity)
PtmPhosphorylated at Ser-350 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli (By similarity). Phosphorylation of Ser-350 results in decrease in NBRE binding while phosphorylation of Ser-340 has little effect on it. {ECO:0000250, ECO:0000269|PubMed:8227042}.
Sequence CautionSequence=AAA56770.1; Type=Erroneous initiation; Evidence= ; Sequence=AAH97313.2; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the nuclear hormone receptor family. NR4 subfamily
SimilarityContains 1 nuclear receptor DNA-binding domain
Subcellular LocationCytoplasm . Nucleus.
SubunitInteracts with GADD45GIP1. Interacts with STK11 (By similarity). Binds DNA as a monomer. {ECO:0000250, ECO:0000269|PubMed:10331876}.
Tissue SpecificityExpressed in lung, brain and superior cervical ganglia. High levels are seen in the adrenal tissue.