LIPID MAPS® Gene/Proteome Database (LMPD)

Introduction | Overview of Interfaces | Browse | Search | Download

LMPD Record

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP012769

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol 4-kinase, catalytic, beta
Protein EntryPI4KB_RAT
UniProt IDO08561
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
Enzyme RegulationInhibited by wortmannin. Increased kinase activity upon interaction with NCS1/FREQ (By similarity)
FunctionPhosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking
SimilarityBelongs to the PI3/PI4-kinase family. Type III PI4K subfamily
SimilarityContains 1 PI3K/PI4K domain. {ECO:0000255|PROSITE- ProRule:PRU00269}.
SimilarityContains 1 PIK helical domain. {ECO:0000255|PROSITE- ProRule:PRU00878}.
Subcellular LocationGolgi apparatus {ECO:0000269|PubMed:11526106, ECO:0000269|PubMed:19458041, ECO:0000269|PubMed:8973579}. Endomembrane system . Mitochondrion outer membrane ; Peripheral membrane protein . Rough endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein . Note=Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex (By similarity)
SubunitInteracts with CALN1/CABP8 and CALN2/CABP7; in a calcium- dependent manner. Interacts in a calcium-independent manner with NCS1/FREQ. This binding competes with CALN1/CABP8 and CALN2/CABP7 binding. Interacts with ARF1 and ARF3 (By similarity)
Tissue SpecificityStrongly expressed in brain, kidney, lung, small intestine, uterus and adrenal gland. Weaker expression in liver, heart, skeletal muscle, thymus and testis. Not detected in spleen