LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012786

UniProt Annotations

Entry Information
Gene NameATP-binding cassette, subfamily B (MDR/TAP), member 11
Protein EntryABCBB_RAT
UniProt IDO70127
SpeciesRat
Comments
Comment typeDescription
DomainMultifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.
FunctionInvolved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
InteractionQ7TSE9:Hax1; NbExp=5; IntAct=EBI-930036, EBI-930005;
SimilarityBelongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily
SimilarityContains 2 ABC transmembrane type-1 domains
SimilarityContains 2 ABC transporter domains
Subcellular LocationMembrane; Multi-pass membrane protein.
SubunitInteracts with HAX1
Tissue SpecificityExpressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ.