LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012827

UniProt Annotations

Entry Information
Gene Namephospholipase A1 member A
Protein EntryPLA1A_RAT
UniProt IDP97535
SpeciesRat
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: Vmax=2.6 umol/min/mg enzyme with phosphatidylcholine as substrate ; Vmax=0.1 umol/min/mg enzyme with phosphatidylinositol as substrate ;
FunctionHydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1- acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production
SimilarityBelongs to the AB hydrolase superfamily. Lipase family
Subcellular LocationSecreted .