LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012949

UniProt Annotations

Entry Information
Gene Namealdo-keto reductase family 1, member C3
Protein EntryAKC1H_RAT
UniProt IDP51652
SpeciesRat
Comments
Comment typeDescription
Catalytic Activity17-alpha,20-alpha-dihydroxypregn-4-en-3-one + NAD(P)(+) = 17-alpha-hydroxyprogesterone + NAD(P)H.
Developmental StageRemains repressed throughout pregnancy and becomes highly and rapidly expressed before parturition.
FunctionCatalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP).
InductionRepressed by prolactin.
PtmThe N-terminus is blocked.
SimilarityBelongs to the aldo/keto reductase family
Subcellular LocationCytoplasm.
SubunitMonomer.
Tissue SpecificityCorpus luteum (large luteal cells).