LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012952

UniProt Annotations

Entry Information
Gene Namealdo-keto reductase family 1, member C14
Protein EntryDIDH_RAT
UniProt IDP23457
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityA 3-alpha-hydroxysteroid + NAD(P)(+) = a 3- oxosteroid + NAD(P)H.
Enzyme RegulationPotently inhibited by the nonsteroidal anti- inflammatory drugs (NSAID).
FunctionBesides being a 3-alpha-hydroxysteroid dehydrogenase, the enzyme can accomplish diverse functions: as quinone reductase, as an aromatic alcohol dehydrogenase, as dihydrodiol dehydrogenase, and as 9-, 11-, and 15-hydroxyprostaglandin dehydrogenase.
SimilarityBelongs to the aldo/keto reductase family
Subcellular LocationCytoplasm.
SubunitMonomer
Tissue SpecificityIn brain, highest levels found in olfactory bulb. Moderate levels present in cerebellum, cerebral cortex, hypothalamus and pituitary. Low levels present in amygdala, brain stem, caudate putamen, cingulate cortex, hippocampus, midbrain, and thalamus