LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012974

UniProt Annotations

Entry Information
Gene Nameacyl-CoA synthetase medium-chain family member 2A
Protein EntryACSM2_RAT
UniProt IDO70490
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ;
Developmental StageFirst detected in kidney from 1 week old rats. Not detectable in fetal kidney and in kidney from newborn rats
Enzyme RegulationActivated by monovalent cations, such as potassium, rubidium or ammonium
FunctionHas medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity)
InductionDown-regulated in kidneys from a strain of spontaneously hypertensive rats (SHR). Down-regulated after unilateral ureteral obstruction or unilateral nephrectomy
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family
Subcellular LocationMitochondrion matrix .
SubunitMonomer
Tissue SpecificityDetected in kidney, in proximal tubules