LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012997

UniProt Annotations

Entry Information
Gene Namesphingosine-1-phosphate lyase 1
Protein EntrySGPL1_RAT
UniProt IDQ8CHN6
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivitySphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.
CofactorName=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence= ;
FunctionCleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (By similarity)
PathwayLipid metabolism; sphingolipid metabolism.
SimilarityBelongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily
Subcellular LocationEndoplasmic reticulum membrane ; Single-pass type III membrane protein .
SubunitHomodimer