LIPID MAPS® Gene/Proteome Database (LMPD)

Introduction | Overview of Interfaces | Browse | Search | Download

LMPD Record

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP013030

UniProt Annotations

Entry Information
Gene Nameinsulin induced gene 2
Protein EntryINSI2_RAT
UniProt IDQ80UA9
SpeciesRat
Comments
Comment typeDescription
FunctionMediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR (By similarity)
SimilarityBelongs to the INSIG family
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein .
SubunitBinds to the SCAP-SREBF2 complex only in the presence of sterols. Interacts with RNF139 (By similarity)