LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP013199

Gene Information

Entrez Gene ID301059
Gene Namemyeloid differentiation primary response 88
Gene SymbolMyd88
SpeciesRattus norvegicus
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0005886 IEA:EnsemblCplasma membrane
GO:0014069 IDA:RGDCpostsynaptic density
GO:0043234 IDA:RGDCprotein complex
GO:0005149 IPI:RGDFinterleukin-1 receptor binding
GO:0005102 IPI:RGDFreceptor binding
GO:0005121 IDA:RGDFToll binding
GO:0070935 IEA:EnsemblP3'-UTR-mediated mRNA stabilization
GO:0071260 IEA:EnsemblPcellular response to mechanical stimulus
GO:0019221 IMP:RGDPcytokine-mediated signaling pathway
GO:0050830 ISS:UniProtKBPdefense response to Gram-positive bacterium
GO:0090557 IEA:EnsemblPestablishment of endothelial intestinal barrier
GO:0016064 IEA:EnsemblPimmunoglobulin mediated immune response
GO:0006954 IEA:UniProtKB-KWPinflammatory response
GO:0045087 IEA:UniProtKB-KWPinnate immune response
GO:0007254 IMP:RGDPJNK cascade
GO:0031663 IEA:EnsemblPlipopolysaccharide-mediated signaling pathway
GO:0002755 IEA:EnsemblPMyD88-dependent toll-like receptor signaling pathway
GO:0044130 IEA:EnsemblPnegative regulation of growth of symbiont in host
GO:0045080 IEA:EnsemblPpositive regulation of chemokine biosynthetic process
GO:0043123 TAS:RGDPpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032740 IEA:EnsemblPpositive regulation of interleukin-17 production
GO:0032747 IEA:EnsemblPpositive regulation of interleukin-23 production
GO:0032755 IEA:EnsemblPpositive regulation of interleukin-6 production
GO:0046330 IEA:EnsemblPpositive regulation of JNK cascade
GO:0050671 IEA:EnsemblPpositive regulation of lymphocyte proliferation
GO:0051092 IEA:EnsemblPpositive regulation of NF-kappaB transcription factor activity
GO:0048661 IMP:RGDPpositive regulation of smooth muscle cell proliferation
GO:0032760 IEA:EnsemblPpositive regulation of tumor necrosis factor production
GO:0050727 IEA:EnsemblPregulation of inflammatory response
GO:0070555 IEA:EnsemblPresponse to interleukin-1
GO:0002238 IEA:EnsemblPresponse to molecule of fungal origin
GO:0032494 IEA:EnsemblPresponse to peptidoglycan
GO:0009615 IEA:EnsemblPresponse to virus
GO:0008063 IDA:RGDPToll signaling pathway
GO:0045351 IEA:EnsemblPtype I interferon biosynthetic process
KEGG Pathway Links
KEGG Pathway IDDescription
ko05143African trypanosomiasis
rno05143African trypanosomiasis
ko04210Apoptosis
rno04210Apoptosis
ko05142Chagas disease (American trypanosomiasis)
rno05142Chagas disease (American trypanosomiasis)
rno05161Hepatitis B
ko05168Herpes simplex infection
rno05168Herpes simplex infection
ko05164Influenza A
rno05164Influenza A
ko05134Legionellosis
rno05134Legionellosis
ko05140Leishmaniasis
rno05140Leishmaniasis
ko05144Malaria
rno05144Malaria
ko05162Measles
rno05162Measles
rno04064NF-kappa B signaling pathway
ko05133Pertussis
rno05133Pertussis
ko05132Salmonella infection
rno05132Salmonella infection
ko04620Toll-like receptor signaling pathway
rno04620Toll-like receptor signaling pathway
ko05145Toxoplasmosis
rno05145Toxoplasmosis
ko05152Tuberculosis
rno05152Tuberculosis
REACTOME Pathway Links
REACTOME Pathway IDDescription
5953551Activated TLR4 signalling
5953536Cytokine Signaling in Immune system
5953792Cytosolic sensors of pathogen-associated DNA
5953794DEx/H-box helicases activate type I IFN and inflammatory cytokines production
5953410Immune System
5953409Innate Immune System
5953797Interleukin-1 signaling
5953565MyD88 cascade initiated on plasma membrane
5953562MyD88 dependent cascade initiated on endosome
5953559MyD88-independent cascade
5953550MyD88:Mal cascade initiated on plasma membrane
5953945p75 NTR receptor-mediated signalling
5953946p75NTR recruits signalling complexes
5953947p75NTR signals via NF-kB
5953789RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
5953790RIP-mediated NFkB activation via ZBP1
5953535Signaling by Interleukins
5953395Signalling by NGF
5953381Signal Transduction
5953787TAK1 activates NFkB by phosphorylation and activation of IKKs complex
5953566Toll Like Receptor 10 (TLR10) Cascade
5953555Toll Like Receptor 2 (TLR2) Cascade
5953560Toll Like Receptor 3 (TLR3) Cascade
5953552Toll Like Receptor 4 (TLR4) Cascade
5953567Toll Like Receptor 5 (TLR5) Cascade
5953564Toll Like Receptor 7/8 (TLR7/8) Cascade
5953563Toll Like Receptor 9 (TLR9) Cascade
5953553Toll-Like Receptors Cascades
5953554Toll Like Receptor TLR1:TLR2 Cascade
5953556Toll Like Receptor TLR6:TLR2 Cascade
5953561TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
5954373TRAF6 mediated IRF7 activation
5954377TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
5953788TRAF6 mediated NF-kB activation
5953558TRIF-mediated TLR3/TLR4 signaling
5953791ZBP1(DAI) mediated induction of type I IFNs