LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP013292

UniProt Annotations

Entry Information
Gene Namefatty acid 2-hydroxylase
Protein EntryFA2H_RAT
UniProt IDQ2LAM0
SpeciesRat
Comments
Comment typeDescription
CofactorName=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence= ;
Developmental StageDetected at low levels in sciatic nerve from newborns. Levels increase strongly during the first 3 weeks, and decrease thereafter to reach a low, constitutive level in 4 week olds. Expressed at a low, constitutive level in adults
DomainThe histidine box domains may contain the active site and/or be involved in metal ion binding.
FunctionRequired for alpha-hydroxylation of free fatty acids and the formation of alpha-hydroxylated sphingolipids
InductionUp-regulated in sciatic nerve during myelination. Up- regulated in differentiating cultured Schwann cells
SimilarityBelongs to the sterol desaturase family. SCS7 subfamily
SimilarityContains 1 cytochrome b5 heme-binding domain
Subcellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane ; Multi-pass membrane protein .
Tissue SpecificityDetected in oligodendrocytes (at protein level). Detected in sciatic nerve. {ECO:0000269|PubMed:16998236, ECO:0000269|PubMed:17901466}.