LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP013316

UniProt Annotations

Entry Information
Gene Namecholesterol 25-hydroxylase
Protein EntryCH25H_RAT
UniProt IDQ4QQV7
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityCholesterol + AH(2) + O(2) = 25- hydroxycholesterol + A + H(2)O.
CofactorName=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence= ;
FunctionCatalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing (By similarity). In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation
InductionDown-regulated by testosterone
PtmN-glycosylated
SimilarityBelongs to the sterol desaturase family
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein .
Tissue SpecificityExpressed in testicular macrophages at all stages, with the highest level in 10 day old animals