LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

LMP013350

Gene Information

Entrez Gene ID	312781
Gene Name	low density lipoprotein receptor-related protein 6
Gene Symbol	Lrp6
Species	Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005901	IBA:RefGenome	C	caveola
GO:0009986	IBA:RefGenome	C	cell surface
GO:0031410	IEA:Ensembl	C	cytoplasmic vesicle
GO:0005769	IEA:Ensembl	C	early endosome
GO:0005794	IEA:Ensembl	C	Golgi apparatus
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0043025	IDA:RGD	C	neuronal cell body
GO:0005886	IBA:RefGenome	C	plasma membrane
GO:0043235	IBA:RefGenome	C	receptor complex
GO:0045202	IDA:RGD	C	synapse
GO:0034185	IBA:RefGenome	F	apolipoprotein binding
GO:0015026	IBA:RefGenome	F	coreceptor activity
GO:0071936	IEA:Ensembl	F	coreceptor activity involved in Wnt signaling pathway
GO:0019210	IEA:Ensembl	F	kinase inhibitor activity
GO:0005041	IBA:RefGenome	F	low-density lipoprotein receptor activity
GO:0019534	IEA:Ensembl	F	toxin transporter activity
GO:0042813	IBA:RefGenome	F	Wnt-activated receptor activity
GO:0017147	IBA:RefGenome	F	Wnt-protein binding
GO:0009952	IBA:RefGenome	P	anterior/posterior pattern specification
GO:0090245	IBA:RefGenome	P	axis elongation involved in somitogenesis
GO:0060349	IBA:RefGenome	P	bone morphogenesis
GO:0046849	IBA:RefGenome	P	bone remodeling
GO:0060444	IBA:RefGenome	P	branching involved in mammary gland duct morphogenesis
GO:0060070	IMP:RGD	P	canonical Wnt signaling pathway
GO:0061310	IEA:Ensembl	P	canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development
GO:0061324	IEA:Ensembl	P	canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation
GO:0042074	IEA:Ensembl	P	cell migration involved in gastrulation
GO:0071397	IEA:Ensembl	P	cellular response to cholesterol
GO:0021587	IBA:RefGenome	P	cerebellum morphogenesis
GO:0021795	IEA:Ensembl	P	cerebral cortex cell migration
GO:0021987	IBA:RefGenome	P	cerebral cortex development
GO:0060026	IBA:RefGenome	P	convergent extension
GO:0071542	IEA:Ensembl	P	dopaminergic neuron differentiation
GO:0048596	IBA:RefGenome	P	embryonic camera-type eye morphogenesis
GO:0042733	IEA:Ensembl	P	embryonic digit morphogenesis
GO:0035115	IEA:Ensembl	P	embryonic forelimb morphogenesis
GO:0035116	IEA:Ensembl	P	embryonic hindlimb morphogenesis
GO:0030326	IBA:RefGenome	P	embryonic limb morphogenesis
GO:0009880	IBA:RefGenome	P	embryonic pattern specification
GO:0060059	IBA:RefGenome	P	embryonic retina morphogenesis in camera-type eye
GO:0035261	IBA:RefGenome	P	external genitalia morphogenesis
GO:0060325	IBA:RefGenome	P	face morphogenesis
GO:0021861	IEA:Ensembl	P	forebrain radial glial cell differentiation
GO:0021943	IEA:Ensembl	P	formation of radial glial scaffolds
GO:0001702	IBA:RefGenome	P	gastrulation with mouth forming second
GO:0001947	IEA:Ensembl	P	heart looping
GO:0060596	IEA:Ensembl	P	mammary placode formation
GO:0030901	IBA:RefGenome	P	midbrain development
GO:0030917	IBA:RefGenome	P	midbrain-hindbrain boundary development
GO:0050680	IEA:Ensembl	P	negative regulation of epithelial cell proliferation
GO:0045599	IEA:Ensembl	P	negative regulation of fat cell differentiation
GO:2000151	IEA:Ensembl	P	negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
GO:2000162	IEA:Ensembl	P	negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis
GO:2000168	IEA:Ensembl	P	negative regulation of planar cell polarity pathway involved in neural tube closure
GO:2000164	IEA:Ensembl	P	negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis
GO:2000166	IEA:Ensembl	P	negative regulation of planar cell polarity pathway involved in pericardium morphogenesis
GO:2000149	IEA:Ensembl	P	negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis
GO:0071901	IEA:Ensembl	P	negative regulation of protein serine/threonine kinase activity
GO:0034392	IEA:Ensembl	P	negative regulation of smooth muscle cell apoptotic process
GO:0014033	IBA:RefGenome	P	neural crest cell differentiation
GO:0014029	IBA:RefGenome	P	neural crest formation
GO:0001843	IBA:RefGenome	P	neural tube closure
GO:0042475	IBA:RefGenome	P	odontogenesis of dentin-containing tooth
GO:0060021	IBA:RefGenome	P	palate development
GO:0003344	IBA:RefGenome	P	pericardium morphogenesis
GO:0043065	IEA:Ensembl	P	positive regulation of apoptotic process
GO:0045780	IEA:Ensembl	P	positive regulation of bone resorption
GO:0090263	IEA:Ensembl	P	positive regulation of canonical Wnt signaling pathway
GO:0045787	IEA:Ensembl	P	positive regulation of cell cycle
GO:0007204	IMP:RGD	P	positive regulation of cytosolic calcium ion concentration
GO:0002053	IEA:Ensembl	P	positive regulation of mesenchymal cell proliferation
GO:0045778	IEA:Ensembl	P	positive regulation of ossification
GO:0051091	IBA:RefGenome	P	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944	IBA:RefGenome	P	positive regulation of transcription from RNA polymerase II promoter
GO:2000055	IEA:Ensembl	P	positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
GO:0036342	IEA:Ensembl	P	post-anal tail morphogenesis
GO:0090009	IBA:RefGenome	P	primitive streak formation
GO:0090118	IBA:RefGenome	P	receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
GO:0060284	IEA:Ensembl	P	regulation of cell development
GO:0045598	IBA:RefGenome	P	regulation of fat cell differentiation
GO:0030278	IBA:RefGenome	P	regulation of ossification
GO:0006355	IMP:RGD	P	regulation of transcription, DNA-templated
GO:0051593	IEA:Ensembl	P	response to folic acid
GO:0043434	IEP:RGD	P	response to peptide hormone
GO:0016337	IMP:RGD	P	single organismal cell-cell adhesion
GO:0007268	IMP:RGD	P	synaptic transmission
GO:0021794	IBA:RefGenome	P	thalamus development
GO:0060535	IBA:RefGenome	P	trachea cartilage morphogenesis
GO:0044332	IBA:RefGenome	P	Wnt signaling pathway involved in dorsal/ventral axis specification
GO:0021874	IEA:Ensembl	P	Wnt signaling pathway involved in forebrain neuroblast division
GO:0090244	IBA:RefGenome	P	Wnt signaling pathway involved in somitogenesis

KEGG Pathway Links

KEGG Pathway ID	Description
ko04310	Wnt signaling pathway
rno04310	Wnt signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID	Description
5954029	disassembly of the destruction complex and recruitment of AXIN to the membrane
5953253	Disease
5954026	misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
5954626	negative regulation of TCF-dependent signaling by WNT ligand antagonists
5954637	regulation of FZD by ubiquitination
5954027	RNF mutants show enhanced WNT signaling and proliferation
5953803	Signaling by Wnt
5953965	Signaling by WNT in cancer
5953381	Signal Transduction
5954025	TCF dependent signaling in response to WNT
5954028	XAV939 inhibits tankyrase, stabilizing AXIN