LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP013436

UniProt Annotations

Entry Information
Gene Namephospholipase A2, group XV
Protein EntryPAG15_RAT
UniProt IDQ675A5
SpeciesRat
Comments
Comment typeDescription
Biophysicochemical PropertiespH dependence: Optimum pH is 4.5. ;
Enzyme RegulationTransacylase activity is inhibited by MJ33
FunctionHas transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N- acetylsphingosine and the concomitant release of a lyso- phospholipid
PtmN-glycosylated
SimilarityBelongs to the AB hydrolase superfamily. Lipase family
Subcellular LocationSecreted {ECO:0000250|UniProtKB:Q8NCC3, ECO:0000250|UniProtKB:Q8VEB4}. Lysosome .
Tissue SpecificityWidely expressed. Expressed at highest levels in alveolar macrophages