LMPD Database

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LMP000012

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol 4-kinase, catalytic, beta polypeptide
Protein EntryQ8BKC8_MOUSE
UniProt IDQ8BKC8
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BKC8-1; Sequence=Displayed; Name=2; IsoId=Q8BKC8-2; Sequence=VSP_037135; Note=Contains a phosphoserine at position 294.; Name=3; IsoId=Q8BKC8-3; Sequence=VSP_037134;
Catalytic ActivityATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate. {ECO:0000250|UniProtKB:Q9UBF8}.
Enzyme RegulationInhibited by wortmannin. Increased kinase activity upon interaction with NCS1/FREQ. {ECO:0000250}.
FunctionPhosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity). Involved in Golgi-to-plasma membrane trafficking (By similarity). {ECO:0000250}.
SimilarityBelongs to the PI3/PI4-kinase family. Type III PI4K subfamily. {ECO:0000305}.
SimilarityContains 1 PI3K/PI4K domain. {ECO:0000255|PROSITE- ProRule:PRU00269}.
SimilarityContains 1 PIK helical domain. {ECO:0000255|PROSITE- ProRule:PRU00878}.
Subcellular LocationEndomembrane system {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Rough endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex (By similarity). {ECO:0000250}.
SubunitInteracts with NCS1/FREQ in a calcium-independent manner. Interacts with CALN1/CABP8 and CALN2/CABP7; in a calcium-dependent manner. This binding competes with NCS1/FREQ binding. Interacts with ARF1 and ARF3. {ECO:0000250}.