LMPD Database

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LMP000014

UniProt Annotations

Entry Information
Gene Nameacyl-CoA dehydrogenase family, member 9
Protein EntryACAD9_HUMAN
UniProt IDQ9H845
SpeciesHuman
Comments
Comment typeDescription
CofactorName=FAD; Xref=ChEBI
DiseaseAcyl-CoA dehydrogenase family, member 9, deficiency (ACAD9 deficiency) [MIM
FunctionHas a dehydrogenase activity on palmitoyl-CoA (C16:0) and stearoyl-CoA (C18:0). It is three times more active on palmitoyl-CoA than on stearoyl-CoA. Has little activity on octanoyl-CoA (C8:0), butyryl-CoA (C4:0) or isovaleryl-CoA (5:0).
SimilarityBelongs to the acyl-CoA dehydrogenase family.
Subcellular LocationMitochondrion .
SubunitPart of the mitochondrial complex I assembly (MCIA) complex. The complex comprises at least TMEM126B, NDUFAF1, ECSIT, and ACAD9 (By similarity).
Tissue SpecificityUbiquitously expressed in most normal human tissues and cancer cell lines with high level of expression in heart, skeletal muscles, brain, kidney and liver.