LMPD Database

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LMP000023

UniProt Annotations

Entry Information
Gene Namehydroxysteroid (17-beta) dehydrogenase 2
Protein EntryDHB2_HUMAN
UniProt IDP37059
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=0.21 uM for estradiol ; KM=0.39 uM for testosterone ; KM=0.31 uM for dihydrotestosterone ; KM=0.71 uM for 20-alpha-dihydroprogesterone ; KM=0.78 uM for estrone ; KM=2.63 uM for androstenedione ; Vmax=38 nmol/min/mg enzyme with estradiol as substrate ; Vmax=45 nmol/min/mg enzyme with testosterone as substrate ; Vmax=38 nmol/min/mg enzyme with dihydrotestosterone as substrate ; Vmax=5.6 nmol/min/mg enzyme with 20-alpha-dihydroprogesterone as substrate ; Vmax=6.6 nmol/min/mg enzyme with estrone as substrate ; Vmax=11.5 nmol/min/mg enzyme with androstenedione as substrate ;
Catalytic Activity17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
Catalytic ActivityTestosterone + NAD(+) = androstenedione + NADH.
FunctionCapable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family.
Subcellular LocationMembrane ; Single-pass type II membrane protein .
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/hsd17b2/";