LMPD Database

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LMP000040

UniProt Annotations

Entry Information
Gene Nameacetyl-CoA acetyltransferase 1
Protein EntryTHIL_HUMAN
UniProt IDP24752
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P24752-1; Sequence=Displayed; Name=2; IsoId=P24752-2; Sequence=VSP_056844, VSP_056845; Note=No experimental confirmation available;
Biophysicochemical PropertiesKinetic parameters: KM=4 uM for acetoacetyl coenzyme A ; KM=20 uM for coenzyme A ; KM=8 uM for 2-methylacetoacetyl coenzyme A ; KM=508 uM for acetyl coenzyme A ;
Catalytic Activity2 acetyl-CoA = CoA + acetoacetyl-CoA. {ECO
Disease3-ketothiolase deficiency (3KTD) [MIM
Enzyme RegulationActivated by potassium ions, but not sodium ions.
FunctionPlays a major role in ketone body metabolism.
PtmSuccinylation at Lys-268, adjacent to a coenzyme A binding site. Desuccinylated by SIRT5 (By similarity).
SimilarityBelongs to the thiolase family.
Subcellular LocationMitochondrion.
SubunitHomotetramer.