LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP000061

UniProt Annotations

Entry Information
Gene Namehydroxysteroid (17-beta) dehydrogenase 2
Protein EntryDHB2_MOUSE
UniProt IDP51658
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
Catalytic ActivityTestosterone + NAD(+) = androstenedione + NADH.
FunctionCapable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH (By similarity). {ECO:0000250}.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.