LMPD Database

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LMP000076

UniProt Annotations

Entry Information
Gene Namehydroxysteroid 11-beta dehydrogenase 2
Protein EntryDHI2_MOUSE
UniProt IDP51661
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityAn 11-beta-hydroxysteroid + NAD(+) = an 11- oxosteroid + NADH.
Enzyme RegulationInhibited by glycyrrhetinic acid, carbenoloxone and 11-alpha-OH-progesterone. {ECO:0000250}.
FunctionCatalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
Sequence CautionSequence=CAA62219.1; Type=Frameshift; Positions=383; Evidence={ECO:0000305};
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular LocationMicrosome. Endoplasmic reticulum {ECO:0000305}.
SubunitInteracts with ligand-free cytoplasmic NR3C2. {ECO:0000250}.
Tissue SpecificityHighly expressed in kidney. Also found in colon and small intestine. Not expressed in the adrenal gland.