LMPD Database

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LMP000140

UniProt Annotations

Entry Information
Gene Namehydroxysteroid (11-beta) dehydrogenase 2
Protein EntryDHI2_HUMAN
UniProt IDP80365
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=26.1 nM for cortisol {ECO
Catalytic ActivityAn 11-beta-hydroxysteroid + NAD(+) = an 11- oxosteroid + NADH.
DiseaseApparent mineralocorticoid excess (AME) [MIM
Enzyme RegulationInhibited by glycyrrhetinic acid (derived from liquorice), carbenoloxone and 11-alpha-OH-progesterone.
FunctionCatalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
MiscellaneousConsumption of large amounts of liquorice can lead to apparent mineralocorticoid excess and hypertension.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family.
Subcellular LocationMicrosome . Endoplasmic reticulum .
SubunitInteracts with ligand-free cytoplasmic NR3C2.
Tissue SpecificityFound in placenta, kidney, pancreas, prostate, ovary, small intestine and colon.