LMPD Database

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LMP000167

UniProt Annotations

Entry Information
Gene Nameacyl-CoA dehydrogenase, C-4 to C-12 straight chain
Protein EntryQ5HYG7_HUMAN
UniProt IDQ5T4U5
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P11310-1; Sequence=Displayed; Name=2; IsoId=P11310-2; Sequence=VSP_038420;
Catalytic ActivityA medium-chain acyl-CoA + electron-transfer flavoprotein = a medium-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.
CofactorName=FAD; Xref=ChEBI
DiseaseAcyl-CoA dehydrogenase medium-chain deficiency (ACADMD) [MIM
FunctionThis enzyme is specific for acyl chain lengths of 4 to 16.
MiscellaneousA number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.
MiscellaneousUtilizes the electron transfer flavoprotein (ETF) as electron acceptor that transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).
PathwayLipid metabolism; mitochondrial fatty acid beta- oxidation.
PtmAcetylation at Lys-307 and Lys-311 in proximity of the cofactor-binding sites reduces catalytic activity (By similarity). These sites are deacetylated by SIRT3. {ECO
SimilarityBelongs to the acyl-CoA dehydrogenase family.
Subcellular LocationMitochondrion matrix.
SubunitHomotetramer. Interacts with the heterodimeric electron transfer flavoprotein ETF. {ECO