LMPD Database

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LMP000186

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol glycan anchor biosynthesis, class P
Protein EntryPIGP_HUMAN
UniProt IDP57054
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=B; IsoId=P57054-1; Sequence=Displayed; Name=A; IsoId=P57054-2; Sequence=VSP_004202; Name=C; Synonyms=DCRC-S; IsoId=P57054-3; Sequence=VSP_004203, VSP_004204;
Catalytic ActivityUDP-N-acetyl-D-glucosamine + 1-phosphatidyl- 1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1- phosphatidyl-1D-myo-inositol.
FunctionPart of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
PathwayGlycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis.
SimilarityBelongs to the PIGP family.
Subcellular LocationMembrane ; Multi-pass membrane protein .
SubunitAssociates with PIGA, PIGC, PIGH, PIGQ and DPM2. The latter is not essential for activity.
Tissue SpecificityUbiquitous.