LMPD Database

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LMP000221

UniProt Annotations

Entry Information
Gene Nameannexin A11
Protein EntryANX11_HUMAN
UniProt IDP50995
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P50995-1; Sequence=Displayed; Name=2; IsoId=P50995-2; Sequence=VSP_054553; Note=No experimental confirmation available.;
DomainA pair of annexin repeats may form one binding site for calcium and phospholipid.
FunctionBinds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis. {ECO
SimilarityBelongs to the annexin family.
SimilarityContains 4 annexin repeats.
Subcellular LocationCytoplasm. Melanosome. Nucleus envelope. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Note=Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic apparatus (By similarity). Elevation of intracellular calcium causes relocalization from the nucleoplasm to the nuclear envelope, with little effect on the cytoplasmic pool. Localization to the nuclear envelope is cell- cycle dependent.
SubunitInteracts with S100A6 (By similarity). Interacts with PDCD6 in a calcium-dependent manner. Interacts with KIF23 during cytokinesis. {ECO