LMPD Database

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LMP000231

UniProt Annotations

Entry Information
Gene Namepatatin-like phospholipase domain containing 3
Protein EntryPLPL3_HUMAN
UniProt IDQ9NST1
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NST1-1; Sequence=Displayed; Name=2; IsoId=Q9NST1-2; Sequence=VSP_036222; Note=No experimental confirmation available.;
Catalytic ActivityTriacylglycerol + H(2)O = diacylglycerol + a carboxylate.
DiseaseNon-alcoholic fatty liver disease 1 (NAFLD1) [MIM
FunctionMultifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities.
InductionBy changes in energy balance: down-regulated following very low-calorie diet, whereas refeeding elevates the mRNA level.
PathwayGlycerolipid metabolism; triacylglycerol degradation.
PolymorphismPolymorphic variation at position 148 influences insulin secretion levels and obesity. In obese subjects the body mass index and waist are higher in carriers of the Ile-148 allele. The Ile-148 carriers also display decreased insulin secretion in response to oral glucose tolerance test. Met-148 allele carriers are seemingly more insulin resistant at a lower body mass index.
SimilarityContains 1 patatin domain.
Subcellular LocationMembrane ; Single-pass type II membrane protein .