LMPD Database

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LMP000315

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 7, subfamily a, polypeptide 1
Protein EntryCP7A1_MOUSE
UniProt IDQ64505
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityCholesterol + NADPH + O(2) = 7-alpha- hydroxycholesterol + NADP(+) + H(2)O.
CofactorName=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
FunctionCatalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis. {ECO:0000269|PubMed:14522988}.
InductionUp-regulated by fasting, returns to ground state upon feeding. Up-regulated by experimentally induced diabetes. Down- regulated by insulin treatment. {ECO:0000269|PubMed:14522988, ECO:0000269|PubMed:17636037}.
PathwayLipid metabolism; bile acid biosynthesis.
SimilarityBelongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.