LMPD Database

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LMP000320

UniProt Annotations

Entry Information
Gene Namediacylglycerol O-acyltransferase 2
Protein EntryDGAT2_MOUSE
UniProt IDQ9DCV3
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityAcyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.
Catalytic ActivityAcyl-CoA + retinol = CoA + retinyl ester.
Disruption PhenotypeMice are lipopenic and die soon after birth, apparently from profound reductions in substrates for energy metabolism and from impaired permeability barrier function in the skin. {ECO:0000269|PubMed:14668353}.
Enzyme RegulationInhibited by niacin. {ECO:0000250}.
FunctionEssential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides. Functions also as an acyl-CoA retinol acyltransferase (ARAT) (By similarity). {ECO:0000250}.
InductionIn white adipose tissue, it is regulated by leptin. By insulin. Up-regulated in diabetic mice. Down-regulated upon fasting and replenished upon refeeding in adipose tissue and liver. Down-regulation in obese animals can reduce hepatic lipogenesis and hepatic steatosis as well as attenuate hyperlipidemia, thereby leading to an improvement in metabolic syndrome. {ECO:0000269|PubMed:12413942, ECO:0000269|PubMed:14521909, ECO:0000269|PubMed:16001399}.
PathwayGlycerolipid metabolism; triacylglycerol biosynthesis.
SimilarityBelongs to the diacylglycerol acyltransferase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Lipid droplet {ECO:0000250}.
SubunitForms multimeric complexes consisting of several DGAT2 subunits. {ECO:0000250}.
Tissue SpecificityPredominantly expressed in liver. Also expressed in testis. {ECO:0000269|PubMed:11481335}.