LMPD Database

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LMP000349

UniProt Annotations

Entry Information
Gene Namenuclear receptor subfamily 1, group I, member 2
Protein EntryNR1I2_HUMAN
UniProt IDO75469
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=7; Name=1A; Synonyms=1, PRR1-A; IsoId=O75469-1; Sequence=Displayed; Name=1B; Synonyms=PRR1-B; IsoId=O75469-2; Sequence=VSP_003668; Name=1C; Synonyms=PRR1-C; IsoId=O75469-3; Sequence=VSP_003667; Name=2A; Synonyms=2, PRR2-A; IsoId=O75469-4; Sequence=VSP_003669; Name=2B; Synonyms=PRR2-B; IsoId=O75469-5; Sequence=VSP_003668, VSP_003669; Name=2C; Synonyms=PRR2-C; IsoId=O75469-6; Sequence=VSP_003667, VSP_003669; Name=3; IsoId=O75469-7; Sequence=VSP_026669;
FunctionNuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. {ECO
InteractionP08238:HSP90AB1; NbExp=2; IntAct=EBI-3905991, EBI-352572;
SimilarityBelongs to the nuclear hormone receptor family. NR1 subfamily.
SimilarityContains 1 nuclear receptor DNA-binding domain.
Subcellular LocationNucleus {ECO
SubunitHeterodimer with RXR. Interacts with NCOA1. {ECO
Tissue SpecificityExpressed in liver, colon and small intestine.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/nr1i2/";