LMPD Database

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LMP000370

UniProt Annotations

Entry Information
Gene Namephospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
Protein EntryPAFA_MOUSE
UniProt IDQ60963
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H(2)O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.
FunctionModulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.
Sequence CautionSequence=AAC52274.1; Type=Frameshift; Positions=342, 349; Evidence={ECO:0000305};
SimilarityBelongs to the AB hydrolase superfamily. Lipase family. {ECO:0000305}.
Subcellular LocationSecreted, extracellular space.
Tissue SpecificityPlasma.