LMPD Database

LMP000506

Gene Information

Entrez Gene ID	5170
Gene Name	3-phosphoinositide dependent protein kinase 1
Gene Symbol	PDPK1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0030054	IEA:UniProtKB-KW	C	cell junction
GO:0042995	IDA:BHF-UCL	C	cell projection
GO:0005737	IDA:UniProtKB	C	cytoplasm
GO:0016023	IEA:Ensembl	C	cytoplasmic membrane-bounded vesicle
GO:0005829	TAS:Reactome	C	cytosol
GO:0005654	TAS:Reactome	C	nucleoplasm
GO:0005886	IDA:UniProtKB	C	plasma membrane
GO:0004676	IDA:BHF-UCL	F	3-phosphoinositide-dependent protein kinase activity
GO:0005524	IEA:UniProtKB-KW	F	ATP binding
GO:0016301	EXP:Reactome	F	kinase activity
GO:0016004	IMP:BHF-UCL	F	phospholipase activator activity
GO:0043274	IPI:BHF-UCL	F	phospholipase binding
GO:0004674	IDA:BHF-UCL	F	protein serine/threonine kinase activity
GO:0030036	TAS:ProtInc	P	actin cytoskeleton organization
GO:0032148	IDA:BHF-UCL	P	activation of protein kinase B activity
GO:0007596	TAS:Reactome	P	blood coagulation
GO:0019722	IMP:BHF-UCL	P	calcium-mediated signaling
GO:0016477	IMP:BHF-UCL	P	cell migration
GO:0071364	IMP:BHF-UCL	P	cellular response to epidermal growth factor stimulus
GO:0032869	IMP:BHF-UCL	P	cellular response to insulin stimulus
GO:0007173	IMP:BHF-UCL	P	epidermal growth factor receptor signaling pathway
GO:0097191	IMP:UniProtKB	P	extrinsic apoptotic signaling pathway
GO:0038095	TAS:Reactome	P	Fc-epsilon receptor signaling pathway
GO:0008543	TAS:Reactome	P	fibroblast growth factor receptor signaling pathway
GO:0048041	IEA:Ensembl	P	focal adhesion assembly
GO:0006972	IEA:Ensembl	P	hyperosmotic response
GO:0045087	TAS:Reactome	P	innate immune response
GO:0008286	TAS:Reactome	P	insulin receptor signaling pathway
GO:0035556	IDA:MGI	P	intracellular signal transduction
GO:0010667	IEA:Ensembl	P	negative regulation of cardiac muscle cell apoptotic process
GO:0006469	IDA:BHF-UCL	P	negative regulation of protein kinase activity
GO:0034122	IEA:Ensembl	P	negative regulation of toll-like receptor signaling pathway
GO:0030512	IDA:UniProtKB	P	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0048011	TAS:Reactome	P	neurotrophin TRK receptor signaling pathway
GO:0018107	IDA:BHF-UCL	P	peptidyl-threonine phosphorylation
GO:0048015	TAS:Reactome	P	phosphatidylinositol-mediated signaling
GO:0030168	TAS:Reactome	P	platelet activation
GO:0090004	IMP:BHF-UCL	P	positive regulation of establishment of protein localization to plasma membrane
GO:0010518	IMP:BHF-UCL	P	positive regulation of phospholipase activity
GO:0051281	IDA:BHF-UCL	P	positive regulation of release of sequestered calcium ion into cytosol
GO:0046777	TAS:UniProtKB	P	protein autophosphorylation
GO:0006468	IDA:UniProtKB	P	protein phosphorylation
GO:0010594	IEA:Ensembl	P	regulation of endothelial cell migration
GO:0043122	IMP:UniProtKB	P	regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043304	IEA:Ensembl	P	regulation of mast cell degranulation
GO:0006355	IEA:UniProtKB-KW	P	regulation of transcription, DNA-templated
GO:0007268	TAS:Reactome	P	synaptic transmission
GO:0031295	TAS:Reactome	P	T cell costimulation
GO:0050852	TAS:Reactome	P	T cell receptor signaling pathway
GO:0006351	IEA:UniProtKB-KW	P	transcription, DNA-templated
GO:0003323	IEA:Ensembl	P	type B pancreatic cell development

KEGG Pathway Links

KEGG Pathway ID	Description
hsa04152	AMPK signaling pathway
hsa04068	FoxO signaling pathway
hsa05205	Proteoglycans in cancer
hsa04919	Thyroid hormone signaling pathway