LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP000545

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol glycan anchor biosynthesis, class C
Protein EntryPIGC_HUMAN
UniProt IDQ92535
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityUDP-N-acetyl-D-glucosamine + 1-phosphatidyl- 1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1- phosphatidyl-1D-myo-inositol.
FunctionPart of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
PathwayGlycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis.
SimilarityBelongs to the PIGC family.
Subcellular LocationEndoplasmic reticulum membrane {ECO
SubunitAssociates with PIGA, PIGH, PIGP, PIGQ and DPM2. The latter is not essential for activity.
Web ResourceName=Functional Glycomics Gateway - GTase; Note=Phosphatidylinositol N-acetylglucosaminyltransferase subunit C8; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_556";