LMPD Database

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LMP000593

UniProt Annotations

Entry Information
Gene Namephospholipase C, beta 4
Protein EntryPLCB4_HUMAN
UniProt IDQ15147
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Comment=Additional isoforms seem to exist.; Name=2; IsoId=Q15147-1; Sequence=Displayed; Name=1; IsoId=Q15147-2; Sequence=VSP_004721, VSP_004722; Name=3; IsoId=Q15147-4; Sequence=VSP_037818; Note=No experimental confirmation available.; Name=4; IsoId=Q15147-5; Sequence=VSP_055182; Note=No experimental confirmation available.;
Catalytic Activity1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
CofactorName=Ca(2+); Xref=ChEBI
DiseaseAuriculocondylar syndrome 2 (ARCND2) [MIM
FunctionThe production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction.
SimilarityContains 1 C2 domain. {ECO
SimilarityContains 1 PI-PLC X-box domain. {ECO
SimilarityContains 1 PI-PLC Y-box domain. {ECO
Tissue SpecificityPreferentially expressed in the retina.