LMPD Database

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LMP000616

UniProt Annotations

Entry Information
Gene Nameinositol polyphosphate 5-phosphatase J
Protein EntryPI5PA_MOUSE
UniProt IDP59644
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity1D-myo-inositol 1,3,4,5-tetrakisphosphate + H(2)O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.
Catalytic ActivityD-myo-inositol 1,4,5-trisphosphate + H(2)O = myo-inositol 1,4-bisphosphate + phosphate.
DomainThe 5 Arg-Ser-Xaa-Ser-Xaa-Xaa (RSXSXX) motifs may constitute binding sites for the 14-3-3 protein.
FunctionInositol 5-phosphatase, which converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4- phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate- binding proteins that are present at membranes ruffles (By similarity). {ECO:0000250}.
SimilarityBelongs to the inositol 1,4,5-trisphosphate 5- phosphatase type II family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:12536145}. Note=Predominantly localized to membrane ruffles.