LMPD Database

LMP000761

Gene Information

Entrez Gene ID	5743
Gene Name	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Gene Symbol	PTGS2
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IDA:UniProtKB	C	cytoplasm
GO:0005789	TAS:Reactome	C	endoplasmic reticulum membrane
GO:0043005	IDA:MGI	C	neuron projection
GO:0005634	ISS:UniProtKB	C	nucleus
GO:0043234	IEA:Ensembl	C	protein complex
GO:0050473	TAS:Reactome	F	arachidonate 15-lipoxygenase activity
GO:0019899	IPI:UniProtKB	F	enzyme binding
GO:0020037	ISS:UniProtKB	F	heme binding
GO:0008289	IEA:Ensembl	F	lipid binding
GO:0046872	IEA:UniProtKB-KW	F	metal ion binding
GO:0004601	NAS:UniProtKB	F	peroxidase activity
GO:0004666	IDA:UniProtKB	F	prostaglandin-endoperoxide synthase activity
GO:0042640	IEA:Ensembl	P	anagen
GO:0001525	IEA:Ensembl	P	angiogenesis
GO:0019369	TAS:Reactome	P	arachidonic acid metabolic process
GO:0030282	IEA:Ensembl	P	bone mineralization
GO:0050873	IEA:Ensembl	P	brown fat cell differentiation
GO:0006928	TAS:ProtInc	P	cellular component movement
GO:0071318	IEA:Ensembl	P	cellular response to ATP
GO:0071456	IEP:UniProtKB	P	cellular response to hypoxia
GO:0071260	IEA:Ensembl	P	cellular response to mechanical stimulus
GO:0034644	IEA:Ensembl	P	cellular response to UV
GO:0019371	IDA:BHF-UCL	P	cyclooxygenase pathway
GO:0046697	IEA:Ensembl	P	decidualization
GO:0007566	IEA:Ensembl	P	embryo implantation
GO:0006954	IEA:Ensembl	P	inflammatory response
GO:0007612	IEA:Ensembl	P	learning
GO:0019372	TAS:Reactome	P	lipoxygenase pathway
GO:0035633	IEA:Ensembl	P	maintenance of blood-brain barrier
GO:0007613	IEA:Ensembl	P	memory
GO:0051926	IEA:Ensembl	P	negative regulation of calcium ion transport
GO:0045786	IEA:Ensembl	P	negative regulation of cell cycle
GO:0008285	IEA:Ensembl	P	negative regulation of cell proliferation
GO:0045986	IEA:Ensembl	P	negative regulation of smooth muscle contraction
GO:0032227	IEA:Ensembl	P	negative regulation of synaptic transmission, dopaminergic
GO:0030728	IEA:Ensembl	P	ovulation
GO:0043065	IEA:Ensembl	P	positive regulation of apoptotic process
GO:0090336	ISS:BHF-UCL	P	positive regulation of brown fat cell differentiation
GO:0090050	ISS:BHF-UCL	P	positive regulation of cell migration involved in sprouting angiogenesis
GO:0031622	ISS:BHF-UCL	P	positive regulation of fever generation
GO:0090271	ISS:BHF-UCL	P	positive regulation of fibroblast growth factor production
GO:0042346	IEA:Ensembl	P	positive regulation of NF-kappaB import into nucleus
GO:0045429	ISS:BHF-UCL	P	positive regulation of nitric oxide biosynthetic process
GO:0090362	ISS:BHF-UCL	P	positive regulation of platelet-derived growth factor production
GO:0031394	NAS:BHF-UCL	P	positive regulation of prostaglandin biosynthetic process
GO:0048661	IEA:Ensembl	P	positive regulation of smooth muscle cell proliferation
GO:0045987	IEA:Ensembl	P	positive regulation of smooth muscle contraction
GO:0031915	IEA:Ensembl	P	positive regulation of synaptic plasticity
GO:0051968	IEA:Ensembl	P	positive regulation of synaptic transmission, glutamatergic
GO:0071636	ISS:BHF-UCL	P	positive regulation of transforming growth factor beta production
GO:0045907	IEA:Ensembl	P	positive regulation of vasoconstriction
GO:0010575	ISS:BHF-UCL	P	positive regulation vascular endothelial growth factor production
GO:0001516	ISS:UniProtKB	P	prostaglandin biosynthetic process
GO:0006693	TAS:ProtInc	P	prostaglandin metabolic process
GO:0008217	ISS:UniProtKB	P	regulation of blood pressure
GO:0050727	NAS:UniProtKB	P	regulation of inflammatory response
GO:0042493	IEA:Ensembl	P	response to drug
GO:0032355	IEA:Ensembl	P	response to estradiol
GO:0070542	IEA:Ensembl	P	response to fatty acid
GO:0009750	IEA:Ensembl	P	response to fructose
GO:0051384	IEA:Ensembl	P	response to glucocorticoid
GO:0032496	IEA:Ensembl	P	response to lipopolysaccharide
GO:0010226	IEA:Ensembl	P	response to lithium ion
GO:0010042	IEA:Ensembl	P	response to manganese ion
GO:0006979	IEA:InterPro	P	response to oxidative stress
GO:0034612	IEA:Ensembl	P	response to tumor necrosis factor
GO:0033280	IEA:Ensembl	P	response to vitamin D
GO:0019233	IEA:Ensembl	P	sensory perception of pain
GO:0044281	TAS:Reactome	P	small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID	Description
hsa05206	MicroRNAs in cancer
hsa04913	Ovarian steroidogenesis
hsa04921	Oxytocin signaling pathway
hsa04668	TNF signaling pathway