LMPD Database

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LMP000792

UniProt Annotations

Entry Information
Gene NameCDP-diacylglycerol synthase 1
Protein EntryCDS1_MOUSE
UniProt IDP98191
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityCTP + phosphatidate = diphosphate + CDP- diacylglycerol.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Developmental StageExpressed in a structure probably corresponding to the thymic rudiment at embryonic day 12.5 of gestation (E12.5). No expression could be detected at earlier and later stages of embryonic development (E10.5 and E17.5).
FunctionProvides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells (By similarity). {ECO:0000250}.
PathwayPhospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
SimilarityBelongs to the CDS family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Cytoplasmic aspect of the endoplasmic reticulum. {ECO:0000250}.
SubunitInteracts with FOS; this interaction may enhance catalytic activity. {ECO:0000269|PubMed:22105363}.
Tissue SpecificityHighly expressed in the inner segment of the photoreceptor layer of adult retina. {ECO:0000269|PubMed:9889000}.