LMPD Database

LMP000816

Gene Information

Entrez Gene ID	19225
Gene Name	prostaglandin-endoperoxide synthase 2
Gene Symbol	Ptgs2
Species	Mus musculus

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IDA:MGI	C	cytoplasm
GO:0005783	IEA:UniProtKB-KW	C	endoplasmic reticulum
GO:0016020	IEA:UniProtKB-KW	C	membrane
GO:0043005	IDA:MGI	C	neuron projection
GO:0043234	IEA:Ensembl	C	protein complex
GO:0020037	IDA:UniProtKB	F	heme binding
GO:0008289	IEA:Ensembl	F	lipid binding
GO:0046872	IEA:UniProtKB-KW	F	metal ion binding
GO:0016702	IEA:Ensembl	F	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0004601	IEA:UniProtKB-KW	F	peroxidase activity
GO:0004666	IDA:UniProtKB	F	prostaglandin-endoperoxide synthase activity
GO:0042803	IPI:UniProtKB	F	protein homodimerization activity
GO:0042640	IMP:MGI	P	anagen
GO:0001525	IEA:Ensembl	P	angiogenesis
GO:0030282	ISO:MGI	P	bone mineralization
GO:0050873	IMP:BHF-UCL	P	brown fat cell differentiation
GO:0071318	IEA:Ensembl	P	cellular response to ATP
GO:0071456	IEA:Ensembl	P	cellular response to hypoxia
GO:0071260	IEA:Ensembl	P	cellular response to mechanical stimulus
GO:0034644	IEA:Ensembl	P	cellular response to UV
GO:0019371	IDA:UniProtKB	P	cyclooxygenase pathway
GO:0046697	IEA:Ensembl	P	decidualization
GO:0007566	IEA:Ensembl	P	embryo implantation
GO:0006954	IEA:Ensembl	P	inflammatory response
GO:0030216	NAS:UniProtKB	P	keratinocyte differentiation
GO:0007612	IEA:Ensembl	P	learning
GO:0035633	IEA:Ensembl	P	maintenance of blood-brain barrier
GO:0007613	IEA:Ensembl	P	memory
GO:0051926	IEA:Ensembl	P	negative regulation of calcium ion transport
GO:0045786	IEA:Ensembl	P	negative regulation of cell cycle
GO:0008285	IEA:Ensembl	P	negative regulation of cell proliferation
GO:0045986	IEA:Ensembl	P	negative regulation of smooth muscle contraction
GO:0032227	IEA:Ensembl	P	negative regulation of synaptic transmission, dopaminergic
GO:0030728	IEA:Ensembl	P	ovulation
GO:0043065	IEA:Ensembl	P	positive regulation of apoptotic process
GO:0090336	IMP:BHF-UCL	P	positive regulation of brown fat cell differentiation
GO:0090050	IEA:Ensembl	P	positive regulation of cell migration involved in sprouting angiogenesis
GO:0031622	IDA:BHF-UCL	P	positive regulation of fever generation
GO:0090271	IEA:Ensembl	P	positive regulation of fibroblast growth factor production
GO:0042346	IEA:Ensembl	P	positive regulation of NF-kappaB import into nucleus
GO:0045429	IEA:Ensembl	P	positive regulation of nitric oxide biosynthetic process
GO:0090362	IEA:Ensembl	P	positive regulation of platelet-derived growth factor production
GO:0048661	IEA:Ensembl	P	positive regulation of smooth muscle cell proliferation
GO:0045987	IEA:Ensembl	P	positive regulation of smooth muscle contraction
GO:0031915	IEA:Ensembl	P	positive regulation of synaptic plasticity
GO:0051968	IEA:Ensembl	P	positive regulation of synaptic transmission, glutamatergic
GO:0071636	IEA:Ensembl	P	positive regulation of transforming growth factor beta production
GO:0045907	IEA:Ensembl	P	positive regulation of vasoconstriction
GO:0010575	IEA:Ensembl	P	positive regulation vascular endothelial growth factor production
GO:0001516	IDA:UniProtKB	P	prostaglandin biosynthetic process
GO:0008217	IMP:MGI	P	regulation of blood pressure
GO:0042127	IGI:MGI	P	regulation of cell proliferation
GO:0042493	IEA:Ensembl	P	response to drug
GO:0032355	IEA:Ensembl	P	response to estradiol
GO:0070542	IEA:Ensembl	P	response to fatty acid
GO:0009750	IEA:Ensembl	P	response to fructose
GO:0051384	IEA:Ensembl	P	response to glucocorticoid
GO:0032496	IEA:Ensembl	P	response to lipopolysaccharide
GO:0010226	IEA:Ensembl	P	response to lithium ion
GO:0010042	IEA:Ensembl	P	response to manganese ion
GO:0006979	IEA:InterPro	P	response to oxidative stress
GO:0034612	IEA:Ensembl	P	response to tumor necrosis factor
GO:0033280	IEA:Ensembl	P	response to vitamin D
GO:0019233	IEA:Ensembl	P	sensory perception of pain

KEGG Pathway Links

KEGG Pathway ID	Description
mmu05206	MicroRNAs in cancer
mmu04913	Ovarian steroidogenesis
mmu04921	Oxytocin signaling pathway
mmu04668	TNF signaling pathway