LMPD Database

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LMP000940

UniProt Annotations

Entry Information
Gene Nameprotein arginine methyltransferase 2
Protein EntryANM2_HUMAN
UniProt IDP55345
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=7; Name=1; IsoId=P55345-1; Sequence=Displayed; Name=2; IsoId=P55345-2; Sequence=VSP_042680; Note=No experimental confirmation available.; Name=3; IsoId=P55345-3; Sequence=VSP_043381; Note=No experimental confirmation available.; Name=PRMT2Alpha; IsoId=P55345-4; Sequence=VSP_054930, VSP_054931; Note=Higher expression in breast cancer tissues.; Name=PRMT2Beta; IsoId=P55345-5; Sequence=VSP_054928, VSP_054932; Note=Higher expression in breast cancer tissues. Doesn't interact with ESR1.; Name=PRMT2Gamma; IsoId=P55345-6; Sequence=VSP_054927; Note=Higher expression in breast cancer tissues.; Name=PRMT2L2; IsoId=P55345-7; Sequence=VSP_054929;
Biophysicochemical PropertiesKinetic parameters: KM=2.6 uM for AdoMet ; KM=3.3 uM for H4 ; Vmax=1.4 nmol/min/mg enzyme toward AdoMet ; Vmax=1.5 nmol/min/mg enzyme toward H4 ;
Catalytic ActivityS-adenosyl-L-methionine + arginine-[histone] = S-adenosyl-L-homocysteine + N(omega)-methyl-arginine-[histone].
FunctionArginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1- dependent manner). May be involved in growth regulation. {ECO
InteractionP03372:ESR1; NbExp=9; IntAct=EBI-78458, EBI-78473; P06400:RB1; NbExp=3; IntAct=EBI-78458, EBI-491274;
SimilarityBelongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N- methyltransferase family.
SimilarityContains 1 SAM-dependent MTase PRMT-type domain.
SimilarityContains 1 SH3 domain. {ECO
Subcellular LocationIsoform 1: Cytoplasm. Nucleus. Note=Translocates from the cytoplasm to the nucleus, after hormone exposure. Excluded from nucleolus.
Subcellular LocationIsoform PRMT2Alpha: Nucleus. Note=Excluded from nucleolus.
Subcellular LocationIsoform PRMT2Beta: Cytoplasm. Nucleus. Nucleus, nucleolus.
Subcellular LocationIsoform PRMT2Gamma: Nucleus. Note=Excluded from nucleolus.
Subcellular LocationIsoform PRMT2L2: Cytoplasm . Nucleus . Note=Predominantly cytoplasmic.
SubunitSelf-associates. Interacts with RB1 and E2F1 (By similarity). Interacts with NCOA6 coactivator. Interacts (via SH3 domain) with PRMT8. Interacts with AR. Interacts with NFKBIA. Interacts with ESR1, ESR2, PGR, PPARG, RARA, RXRA and THRB. Interacts with HNRNPUL1. {ECO
Tissue SpecificityWidely expressed. Highly expressed in androgen target organs such as heart, prostate, skeletal muscle, ovary and spinal cord.