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LMPD Database

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LMP000977

UniProt Annotations

Entry Information

Gene Name	fatty acid binding protein 4, adipocyte
Protein Entry	FABP4_MOUSE
UniProt ID	P04117
Species	Mouse

Comments

Comment type	Description
Domain	Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
Function	Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus. {ECO:0000269\|PubMed:12077340, ECO:0000269\|PubMed:16574478, ECO:0000269\|PubMed:17516629}.
Similarity	Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. {ECO:0000305}.
Subcellular Location	Cytoplasm. Nucleus. Note=Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export.
Subunit	Monomer (By similarity). Homodimer. Interacts with PPARG. {ECO:0000250, ECO:0000269\|PubMed:12077340, ECO:0000269\|PubMed:14594993, ECO:0000269\|PubMed:16574478, ECO:0000269\|PubMed:17761196, ECO:0000269\|PubMed:7929228, ECO:0000269\|PubMed:8161548}.