LMPD Database

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LMP000988

UniProt Annotations

Entry Information
Gene Namealcohol dehydrogenase 5 (class III), chi polypeptide
Protein EntryADHX_MOUSE
UniProt IDP28474
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityAn alcohol + NAD(+) = an aldehyde or ketone + NADH.
Catalytic ActivityS-(hydroxymethyl)glutathione + NAD(P)(+) = S- formylglutathione + NAD(P)H.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000250};
FunctionClass-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.
SimilarityBelongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomodimer.
Tissue SpecificityUbiquitous. {ECO:0000269|PubMed:7738026}.