LMPD Database

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LMP001024

UniProt Annotations

Entry Information
Gene Namealdo-keto reductase family 1, member C6
Protein EntryDHB5_MOUSE
UniProt IDP70694
SpeciesMouse
Comments
Comment typeDescription
FunctionActive toward androgens, estrogens, and xenobiotic substrates. Also exhibits low 20 alpha-HSD activity. Shows a- stereospecificity in hydrogen transfer between cofactors and substrates (A-specific). Preferentially catalyzes the reduction of 4-androstenedione, 5-alpha-androstane-3,17-dione, androsterone and dehydroepiandrosterone to testosterone, dihydrotestosterone, 5- alpha-androstane-3-alpha,17-beta-diol and 5-androstene-3-beta,17- beta-diol, respectively. {ECO:0000269|PubMed:10500239}.
PtmThree forms are detected, probably due to post-translational modifications.
SimilarityBelongs to the aldo/keto reductase family. {ECO:0000305}.
SubunitMonomer.
Tissue SpecificityMainly found in liver. Also expressed weakly in kidney. {ECO:0000269|PubMed:10500239}.