LMPD Database

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LMP001043

UniProt Annotations

Entry Information
Gene Namecholine kinase alpha
Protein EntryCHKA_HUMAN
UniProt IDP35790
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P35790-1; Sequence=Displayed; Name=2; IsoId=P35790-2; Sequence=VSP_009683;
Biophysicochemical PropertiesKinetic parameters: KM=0.2 mM for choline {ECO
Catalytic ActivityATP + choline = ADP + phosphocholine.
Catalytic ActivityATP + ethanolamine = ADP + O- phosphoethanolamine.
FunctionHas a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.
PathwayPhospholipid metabolism; phosphatidylcholine biosynthesis; phosphocholine from choline: step 1/1.
PathwayPhospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.
SimilarityBelongs to the choline/ethanolamine kinase family.
Subcellular LocationCytoplasm.
SubunitHeterodimer with CHKB (By similarity). Homodimer. {ECO
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CHKAID44009ch11q13.html";