LMPD Database

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LMP001056

UniProt Annotations

Entry Information
Gene Nameleukotriene A4 hydrolase
Protein EntryLKHA4_HUMAN
UniProt IDP09960
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; Synonyms=L-LTA4; IsoId=P09960-1; Sequence=Displayed; Name=2; Synonyms=S-LTA4; IsoId=P09960-2; Sequence=VSP_041108, VSP_041109; Name=3; IsoId=P09960-3; Sequence=VSP_041107, VSP_041108, VSP_041109; Name=4; IsoId=P09960-4; Sequence=VSP_041107; Note=No experimental confirmation available.;
Catalytic Activity(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa- 7,9,11,14-tetraenoate + H(2)O = (6Z,8E,10E,14Z)-(5S,12R)-5,12- dihydroxyicosa-6,8,10,14-tetraenoate. {ECO
CofactorName=Zn(2+); Xref=ChEBI
Enzyme RegulationInhibited by bestatin. Subject to suicide inhibition by leukotriene A4, due to the formation of a covalent adduct at Tyr-379.
FunctionEpoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity. {ECO
PathwayLipid metabolism; leukotriene B4 biosynthesis.
PtmPhosphorylation at Ser-416 inhibits enzymatic activity.
SimilarityBelongs to the peptidase M1 family.
Subcellular LocationCytoplasm.
SubunitMonomer. {ECO
Tissue SpecificityIsoform 1 and isoform 2 are expressed in monocytes, lymphocytes, neutrophils, reticulocytes, platelets and fibroblasts.