LMPD Database

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LMP001078

UniProt Annotations

Entry Information
Gene Nameglyceronephosphate O-acyltransferase
Protein EntryGNPAT_HUMAN
UniProt IDO15228
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O15228-1; Sequence=Displayed; Name=2; IsoId=O15228-2; Sequence=VSP_056435; Note=No experimental confirmation available.;
Catalytic ActivityAcyl-CoA + glycerone phosphate = CoA + acylglycerone phosphate.
DiseaseRhizomelic chondrodysplasia punctata 2 (RCDP2) [MIM
DomainThe HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
PathwayMembrane lipid metabolism; glycerophospholipid metabolism.
SimilarityBelongs to the GPAT/DAPAT family.
Subcellular LocationPeroxisome membrane ; Peripheral membrane protein ; Matrix side . Note=Exclusively localized to the lumenal side of the peroxisomal membrane.
SubunitMay be part of a heterotrimeric complex composed of DAP- AT, ADAP-S and a modified form of DAP-AT.