LMPD Database

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LMP001084

UniProt Annotations

Entry Information
Gene Namehydroxysteroid (11-beta) dehydrogenase 1
Protein EntryDHI1_HUMAN
UniProt IDP28845
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityAn 11-beta-hydroxysteroid + NADP(+) = an 11- oxosteroid + NADPH. {ECO
DiseaseCortisone reductase deficiency (CRD) [MIM
FunctionCatalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
PtmGlycosylated. {ECO
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family.
Subcellular LocationEndoplasmic reticulum membrane ; Single-pass type II membrane protein .
SubunitHomodimer. {ECO
Tissue SpecificityWidely expressed. Highest expression in liver.