LMPD Database

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LMP001175

UniProt Annotations

Entry Information
Gene Nameapolipoprotein H (beta-2-glycoprotein I)
Protein EntryAPOH_HUMAN
UniProt IDP02749
SpeciesHuman
Comments
Comment typeDescription
FunctionBinds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
InteractionSelf; NbExp=2; IntAct=EBI-2114682, EBI-2114682; P08519:LPA; NbExp=4; IntAct=EBI-2114682, EBI-9232288; P00747:PLG; NbExp=2; IntAct=EBI-2114682, EBI-999394;
PtmN- and O-glycosylated. PubMed:6587378 also reports glycosylation on 'Asn-188' for their allele. {ECO
SimilarityContains 4 Sushi (CCP/SCR) domains.
Subcellular LocationSecreted.
Tissue SpecificityExpressed by the liver and secreted in plasma.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/apoh/";
Web ResourceName=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=APOH";