LMPD Database

LMP001246

UniProt Annotations

Entry Information
Gene Nameretinoic acid receptor, gamma
Protein EntryRARG_HUMAN
UniProt IDP13631
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Comment=Isoforms differ only in their N-terminal regions.; Name=1; IsoId=P13631-1; Sequence=Displayed; Name=2; IsoId=P13631-2; Sequence=VSP_031080; Name=3; IsoId=P13631-3; Sequence=VSP_044777; Note=No experimental confirmation available.; Name=4; IsoId=P13631-4; Sequence=VSP_044776; Note=No experimental confirmation available.;
DomainComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
FunctionReceptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity)
InteractionO60504-2:SORBS3; NbExp=2; IntAct=EBI-2568901, EBI-1222956;
Sequence CautionSequence=CAA40548.1; Type=Erroneous gene model prediction; Evidence= ;
SimilarityBelongs to the nuclear hormone receptor family. NR1 subfamily
SimilarityContains 1 nuclear receptor DNA-binding domain
Subcellular LocationNucleus.
SubunitHomodimer. Heterodimer with a RXR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Forms a complex with PUS1 and the SRA1 RNA in the nucleus
Web ResourceName=Wikipedia; Note=Retinoic acid receptor entry; URL="http://en.wikipedia.org/wiki/Retinoic_acid_receptor";