LMPD Database

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LMP001277

UniProt Annotations

Entry Information
Gene Namephosphate cytidylyltransferase 1, choline, alpha
Protein EntryPCY1A_HUMAN
UniProt IDP49585
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityCTP + phosphocholine = diphosphate + CDP- choline.
DiseaseSpondylometaphyseal dysplasia with cone-rod dystrophy (SMDCRD) [MIM
Enzyme RegulationBy phosphorylation.
FunctionControls phosphatidylcholine synthesis.
PathwayPhospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.
PtmMonoubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.
PtmThe serine residues of the C-terminus are phosphorylated. The inactive soluble form is stabilized by phosphorylation, the active membrane bound form is promoted by anionic lipids or diacylglycerol, and is stabilized by dephosphorylation (By similarity).
SimilarityBelongs to the cytidylyltransferase family.
Subcellular LocationCytoplasm, cytosol . Membrane {ECO
SubunitHomodimer.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/pcyt1a/";