LMPD Database

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LMP001278

UniProt Annotations

Entry Information
Gene NameST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
Protein EntrySIA8A_MOUSE
UniProt IDQ64687
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityCMP-N-acetylneuraminate + alpha-N- acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N- acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D- galactosyl-R. {ECO:0000269|PubMed:8910600}.
FunctionInvolved in the production of gangliosides GD3 and GT3 from GM3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid. {ECO:0000269|PubMed:8910600}.
PathwayLipid metabolism; sphingolipid metabolism.
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the glycosyltransferase 29 family. {ECO:0000305}.
Subcellular LocationGolgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Web ResourceName=Functional Glycomics Gateway - GTase; Note=ST8Sia I; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_656";